sympathetic nerve activity.
An P, Dang HM, Shi XM, Ye BY, Wu XL. J Ethnopharmacol. 2014
May 26. pii: S0378-8741(14)00388-2. doi: 10.1016/j.jep.2014.05.019. [Epub ahead of print]
Dept of Integrated Chinese Traditional and Western Medicine, 2nd Affiliated Hospital,
Medical School of Xi'an Jiaotong Univ/Shaanxi Province Key TCM Dept of Nephrology, Xi'an
710004, PRC. email@example.com
ETHNOPHARMACOLOGICAL RELEVANCE: Although
the exact mechanism(s) underlying AP remain unknown, AP and AP-like somatic nerve
stimulation have been used to treat different kidney diseases and several complications
related to them.The aim of this preliminary study was to assess the effectiveness of AP on
glomerulonephritis (GN) according to the theory of "Wind-hided renal collaterals" [Phil: KI Luo
Latent Wind (Fengfu Shenluo) / KI Luo Wind Moving (Shenluo Fengdong )]
MATERIAL AND METHODS: We used a New Zealand white rabbit
model of cationized bovine serum albumin (cBSA)-induced glomerulonephritis and then
administered them metoprolol, irbesartan or AP to evaluate the effectiveness of AP treatment
and preliminarily explore its potential mechanism.
RESULTS: After immunization, our results
showed that compared to the cBSA+MET and cBSA+IRB medication groups, "Qufeng
Tongluo" [Phil: , Dispel Wind + Dredge Luo] significantly lowered parameters of
renal function and improved podocyte injury in the 3(rd), 6(th) and 8(th) weeks of treatment.
Moreover, AP increased the protein expression of phosphorylated ERK1/2.
Our study suggests that a potential mechanism by which AP has an antihypertensive effect
and can significantly halt deteriorating renal function due to cBSA GN might be mediated by
inhibiting the Erk1/2 MAPK pathway to reduce renal sympathetic nerve activity (RSNA).
Copyright © 2014. Published by Elsevier Ireland Ltd. PMID: 24875645 [PubMed - as supplied